Bills vs. Chargers Prediction, Odds, Pick For NFL Week 3

The Buffalo Bills host the Los Angeles Chargers on Sunday in a Week 3 NFL matchup. The Bills enter the contest led by head coach Joe Brady and quarterback Josh Allen, boasting the league's top-scoring offense with 38.5 points per game. Meanwhile, the Chargers have opened the season with an 0-2 record following consecutive 26-14 defeats to the Arizona Cardinals and Las Vegas Raiders.

Buffalo's defense has shown vulnerabilities, allowing 31 points per game and ranking 28th overall in total yards allowed. Allen has accounted for nine total touchdowns without committing a turnover through two games. Despite their early struggles, the Chargers are considered 7.5-point underdogs entering the contest against Buffalo.