2026, Week 4: Broncos vs. 49ers – Everything we know

The Denver Broncos travel to face the undefeated San Francisco 49ers in Week 4 on Sunday, October 4, 2026, at Levi's Stadium. Kickoff is scheduled for 2:25 p.m. Mile High time, with the game broadcast on CBS. The Broncos enter the matchup with a 2-1 record following consecutive comeback victories, while the 49ers boast a 3-0 start behind quarterback Brock Purdy.

Denver enters the game as 2.5-point road underdogs against Kyle Shanahan's squad. Wide receivers Jaylen Waddle and Marvin Mims Jr. participated fully in practice for the Broncos, while edge rusher Dondrea Tillman faces doubts due to a hamstring injury. For San Francisco, offensive tackle Trent Williams returned to practice in a limited capacity ahead of Sunday's contest.