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49ers Week 6 Injury And Rotation Watch

The 49ers are 5-0, just left Seattle with a 32-29 win, and somehow still have enough injury concerns to make an undefeated fan base sweat. Winning fixes plenty, but it won’t repair the 49ers’ Week 6 injury report.

Published: Wednesday, 14 October 2026 at 11:08 PM
49ers Week 6 Injury And Rotation Watch
Key Things to Know
  • The 49ers face significant injury and rotation issues ahead of their Week 6 game against Washington.
  • Kyle Shanahan confirmed that receiver Deebo Samuel will miss time after suffering a hamstring injury.
  • Linebacker Dre Greenlaw is appealing a one-game suspension after headbutting Seattle's Ernest Jones IV.
The Story in 60 Seconds

The 5-0 San Francisco 49ers face multiple roster challenges ahead of their Week 6 matchup against Washington on Monday, October 19. Head coach Kyle Shanahan confirmed that receiver Deebo Samuel will miss time due to a hamstring injury, further depleting a wide receiver corps that is already missing Christian Kirk, Ricky Pearsall, and Demarcus Robinson. Additionally, linebacker Dre Greenlaw is appealing a one-game suspension following an incident against Seattle.

Stadium Rant highlights that Mike Evans and Brandin Cooks will take on increased responsibility in Samuel's absence, though Evans is managing a rib injury. Shanahan indicated that Nick Bosa, Kyle Juszczyk, and James Thompson Jr. each have a chance to return for Week 6. Rookie linebacker Jaden Dugger stepped up in Week 5, recording nine tackles and a sack after replacing Greenlaw.

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