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Arizona Cardinals Vs. 49ers: Costly Mistakes Doom Late Comeback

The Arizona Cardinals nearly erased a 17-point deficit in Santa Clara, but the San Francisco 49ers escaped with a 36-30 NFC West victory. Arizona scored 24 of the game’s final 30 points after falling behind 23-6, yet San Francisco answered…

Published: Monday, 28 September 2026 at 5:58 PM
Arizona Cardinals Vs. 49ers: Costly Mistakes Doom Late Comeback
Key Things to Know
  • The San Francisco 49ers defeated the Arizona Cardinals 36-30 despite a late 24-point second-half comeback attempt.
  • Brock Purdy led San Francisco with 297 passing yards and four touchdowns, including two to George Kittle.
  • Jacoby Brissett totaled three touchdowns for Arizona, throwing for 280 yards and rushing for another score.
The Story in 60 Seconds

The San Francisco 49ers held off a second-half rally by the Arizona Cardinals to secure a 36-30 NFC West victory in Santa Clara. Arizona cut a 23-6 deficit down to three points behind a strong offensive second half led by quarterback Jacoby Brissett. However, San Francisco responded with explosive scoring drives to remain undefeated at 3-0, while dropping Arizona to a 1-2 record.

Brock Purdy threw four touchdown passes and totaled 297 yards for the 49ers, connecting twice with tight end George Kittle. Brissett passed for 280 yards and two touchdowns while adding a rushing score for Arizona. The Cardinals were ultimately undone by 10 penalties for 86 yards, including a crucial fourth-quarter roughing-the-passer foul by Josh Sweat that extended a pivotal San Francisco scoring drive.

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