Buffalo Bills Vs. L.A. Rams – Week 5 primetime final score prediction

The Buffalo Bills visit the L.A. Rams for Monday Night Football in Week 5. Can they get back into the win column?

By Iestyn Harris · BuffaLowDown

Published: Sunday, 11 October 2026 at 10:00 AM

Key Things to Know

BuffaLowDown predicts the Buffalo Bills will defeat the Los Angeles Rams 38-31 in Week 5.
Writer Iestyn Harris expects Buffalo's top-ranked scoring offense to rebound following a Week 4 loss to New England.
The Rams' offense, led by receiver Puka Nacua, is projected to heavily challenge Buffalo's struggling pass defense.

The Story in 60 Seconds

BuffaLowDown writer Iestyn Harris previews the Week 5 Monday Night Football matchup between the Buffalo Bills and the Los Angeles Rams, projecting a 38-31 victory for Buffalo. Following a Week 4 defeat against the New England Patriots, the Bills travel to face the Rams in what the author forecasts will be a high-scoring shootout.

Harris expects the Bills' league-leading scoring offense to bounce back behind Josh Allen, while anticipating Rams receiver Puka Nacua will exploit a vulnerable Buffalo pass defense. The prediction reflects an offensive battle similar to their 2024 meeting.

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Buffalo Bills Vs. L.A. Rams – Week 5 primetime final score prediction

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