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Panthers vs. Lions odds: Opening lines for Week 4 matchup

The 1-2 Carolina Panthers are underdogs for their second of two home games so far in the young 2026 season. The 2-1 Lions, however, don’t look quite as fearsome as many Panthers fans projected during the offseason. They beat the…

Published: Sunday, 27 September 2026 at 11:12 PM
Panthers vs. Lions odds: Opening lines for Week 4 matchup
Key Things to Know
  • The Detroit Lions open as 2.5-point favorites against the Carolina Panthers for Week 4.
  • FanDuel set the over/under total for the contest at 48.5 points.
  • Carolina holds a +130 moneyline, while Detroit is listed at -154.
The Story in 60 Seconds

The Carolina Panthers open as 2.5-point home underdogs against the Detroit Lions for their upcoming Week 4 matchup. According to FanDuel opening lines, the Lions are favored at -2.5 (-120) with a moneyline of -154, while the Panthers sit at +2.5 (-102) with a +130 moneyline. The over/under total for the game is set at 48.5 points.

Detroit enters the contest with a 2-1 record following a seven-point victory over the New York Jets, while Carolina stands at 1-2. Key factors highlighted for the Panthers include improving pass protection for quarterback Bryce Young and refining fourth-down decision-making against head coach Dan Campbell's disciplined Lions squad.

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