NFL Week 6 betting: 5 biggest storylines, including how Rams upset loss shook up the odds

The Rams lost to the Cardinals, and it had a ripple effect in the betting market.

By Frank Schwab · Yahoo Sports

Published: Tuesday, 20 October 2026 at 1:58 PM

Key Things to Know

The Los Angeles Rams' upset loss to the Arizona Cardinals shook up NFL betting odds in Week 6.
The Rams' home defeat marked the biggest NFL upset of the season in terms of the point spread.
Los Angeles dropped to 2-4 on the season, while wide receiver Davante Adams suffered an extended injury.

The Story in 60 Seconds

NFL Week 6 betting storylines were highlighted by the Los Angeles Rams suffering an upset loss to the Arizona Cardinals, marking the biggest point-spread upset of the NFL season. The defeat dropped the Rams to a 2-4 record on the season and significantly impacted their overall betting and playoff odds.

Compounding Los Angeles' struggles, wide receiver Davante Adams was ruled out for an extended period due to an injury sustained during the game. Elsewhere around the league, the Kansas City Chiefs remained undefeated, while the Los Angeles Chargers remained winless through six weeks.

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NFL Week 6 betting: 5 biggest storylines, including how Rams upset loss shook up the odds

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