Seahawks vs. 49ers Prediction, Odds, Pick For NFL Week 5

The Seattle Seahawks host the undefeated San Francisco 49ers in an NFL Week 5 divisional matchup. San Francisco enters with a 4-0 record led by quarterback Brock Purdy, who leads the NFL with a 126.2 passer rating. Seattle enters the contest at 3-1 after scoring at least 30 points in three consecutive games and holding the league's top defense in total yards allowed.

FOX Sports Research highlights Seattle's success against Purdy last season, where he threw four interceptions across three meetings. With wide receiver Jaxon Smith-Njigba leading the NFL with six touchdown catches and San Francisco managing various injuries, FOX Sports projects the Seahawks to cover the spread and end the 49ers' unbeaten run.