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Week 7 NFL picks against the spread, predictions for every game: Chiefs look to stay undefeated vs. Seattle

The Seahawks are off to a bit of a disappointing start at 3-3.

Published: Thursday, 22 October 2026 at 12:40 PM
Week 7 NFL picks against the spread, predictions for every game: Chiefs look to stay undefeated vs. Seattle
Key Things to Know
  • Yahoo Sports projects the Seattle Seahawks to defeat the undefeated Kansas City Chiefs against a 2.5-point spread.
  • Kenneth Walker III returns to Seattle leading the NFL with 665 rushing yards after signing with Kansas City.
  • The 3-3 Seahawks face urgency to prevent a three-game losing streak against the 5-0 Chiefs.
The Story in 60 Seconds

Yahoo Sports provides Week 7 NFL betting analysis and predictions against the spread, headlined by an undefeated 5-0 Kansas City Chiefs team visiting the 3-3 Seattle Seahawks. Former Seattle running back Kenneth Walker III leads the league with 665 rushing yards for Kansas City, while the Seahawks enter on a two-game skid behind quarterback Sam Darnold. Yahoo Sports picks Seattle as 2.5-point favorites at home, citing urgency and a formidable defense.

Additional matchups previewed across the league include Drake Maye and Caleb Williams facing off as the Patriots meet the Bears, plus an international contest in Paris between the Steelers and Saints. The column also covers quarterback changes for the Giants, injury concerns for Lamar Jackson and Mike Evans, and turmoil for the Colts following the dismissal of general manager Chris Ballard.

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