NHL Predictions: Ottawa Senators vs Buffalo Sabres, Odds & Picks – November 4

The Ottawa Senators travel to face the Buffalo Sabres at KeyBank Center on Wednesday night in an Atlantic Division matchup. Heading into the contest, Ottawa holds a 9-6-1 record to sit fourth in the division, while Buffalo enters at 7-4-3 in seventh position. The game marks the first of four meetings between the two teams for the 2026-27 season.

Last Word On Hockey highlights key player matchups, noting Dylan Cozens' recent form alongside former Senator Joshua Norris' adaptation to Buffalo. For the Sabres, offensive focal point Tage Thompson enters having scored five goals in his last two games. Last Word On Hockey ultimately predicts a tightly contested 3-2 victory for the visiting Senators.