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Houston Texans Prediction at Colts Week Three

The Texans unfortunately enter familiar territory. For the second straight year and third time in the DeMeco Ryans era, the Texans are 0-2 out of the gate. They face their AFC South rivals the Indianapolis Colts (0-2), who’ve also tripped…

Published: Friday, 25 September 2026 at 1:13 PM
Houston Texans Prediction at Colts Week Three
Key Things to Know
  • Both the Houston Texans and Indianapolis Colts hold 0-2 records heading into their Week Three division matchup.
  • FanDuel odds favor the visiting Texans by 1.5 points over the Colts.
  • Colts running back Jonathan Taylor has rushed for 190 yards through the first two games.
The Story in 60 Seconds

The Houston Texans and Indianapolis Colts both enter their Week Three AFC South matchup seeking their first win after starting the season 0-2. Head coach DeMeco Ryans and the Texans face an Indianapolis team coming off high-scoring defeats against the Baltimore Ravens and Kansas City Chiefs. FanDuel odds list Houston as a 1.5-point favorite heading into the division contest.

Indianapolis leans on running back Jonathan Taylor, who has rushed for 190 yards, while quarterback Daniel Jones has recorded two touchdowns and two interceptions. The Colts will be without receiver Alec Pierce due to an injured reserve designation. Meanwhile, Houston aims to adjust offensively under Nick Caley after C.J. Stroud threw a career-high 55 passes in their previous game.

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