The Arizona Cardinals‘ performance against the NFC West has gotten historically bad following their most recent loss.Sunday’s loss to the San Francisco 49ers gives the Cardinals eight straight losses against their NFC West rivals going back to the beginning of…
The Arizona Cardinals suffered a defeat against the San Francisco 49ers on September 27, 2026, marking their eighth consecutive loss against NFC West opponents dating back to the start of 2025. The Cardinals trailed 23-6 at one point before attempting a comeback led by quarterback Jacoby Brissett, but they never managed to tie or take the lead.
Arizona now holds a 4-22 record against divisional opponents since the beginning of the 2022 season. During the contest, Cardinals running back Jeremiyah Love rushed for 90 yards on 21 carries, while 49ers quarterback Brock Purdy completed 15 passes for 297 yards against Arizona's defense.
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