49ers are the heaviest division favorites in the NFL

San Francisco's odds to win the NFC West are at -650…

By Michael David Smith · NBC Sports

Published: Wednesday, 21 October 2026 at 8:48 AM

Key Things to Know

The San Francisco 49ers are currently the heaviest division favorites in the NFL.
Preseason projections previously expected the Los Angeles Rams to win the NFC West division.
The defending Super Bowl champion Seattle Seahawks were also projected ahead of the 49ers initially.

The Story in 60 Seconds

The San Francisco 49ers have become the heaviest division favorites in the NFL through six weeks of the season. Prior to the campaign, the NFC West was anticipated to be a tight three-team race featuring the Los Angeles Rams and Seattle Seahawks, with San Francisco considered a third-place contender.

Preseason expectations favored the Rams to claim the division title, closely followed by the defending Super Bowl champion Seahawks. However, shifting circumstances six weeks into the regular season have rapidly reshaped the competitive outlook of the NFC West.

Read the full article on NBC Sports

49ers are the heaviest division favorites in the NFL

More NFL News

Never Miss a Sports Update