This will be a fun one. At least we hope it will be, as the Cardinals head up to Santa Clara to take on the Niners and we just want this one to be competitive for four quarters. If that…
The Arizona Cardinals face the San Francisco 49ers in Week 3 of the 2026 NFL season on Sunday, September 27, 2026. Arizona enters the matchup with a 1-1 record, while San Francisco holds a 2-0 record. The contest is set to take place at Levi's Stadium in Santa Clara, California, kicking off at 1:05 p.m. AT.
Television coverage is broadcast nationally on Fox with Kevin Kugler, Daryl Johnston, and Allison Williams calling the action. Local Arizona radio coverage is provided by Arizona Sports 98.7 FM. According to FanDuel Sportsbook, the Cardinals are listed as 8.5-point underdogs heading into the game.
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