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Our guide to every NFL Week 5 game: Matchup previews, predictions, picks and nuggets

Bears vs. Packers? 49ers vs. Seahawks? There are 14 more games in Week 5, and we have picks, predictions and more for all of them.

ESPN

Published: Friday, 9 October 2026 at 1:56 PM

Key Things to Know

ESPN previewed the NFL Week 5 slate with analytical predictions, betting picks, and fantasy guidance.
The Philadelphia Eagles face the Jacksonville Jaguars with major lineup changes following Lane Johnson's retirement.
Bears head coach Ben Johnson named quarterback Tyson Bagent as the starter against the Green Bay Packers.

The Story in 60 Seconds

ESPN provides a comprehensive preview of the NFL Week 5 slate, offering game predictions, betting insights, fantasy advice, and team analysis across key matchups. Prominent contests examined include the Philadelphia Eagles meeting the Jacksonville Jaguars in London, the Chicago Bears taking on the Green Bay Packers at Lambeau Field, and the undefeated Minnesota Vikings visiting the New Orleans Saints.

Key storylines include significant offensive line changes and injuries for the Eagles, Tyson Bagent starting at quarterback for Chicago against Green Bay, and the Vikings relying on running back Aaron Jones Sr. while leading the league in scoring defense.

Read the full article on ESPN

Our guide to every NFL Week 5 game: Matchup previews, predictions, picks and nuggets

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