Our guide to every NFL Week 6 game: Matchup previews, predictions, picks and nuggets

ESPN previewed the Week 6 slate of the 2026 NFL season, providing projections, betting insights, and injury updates across major matchups. Key storylines include wide receiver Marvin Harrison Jr. preparing to play for the Houston Texans against the Jacksonville Jaguars, alongside quarterback C.J. Stroud. Elsewhere, the Chicago Bears evaluate the potential return of quarterback Caleb Williams from a hamstring injury ahead of their matchup with the Atlanta Falcons.

Additional coverage highlights the Baltimore Ravens' division clash against Deshaun Watson and the Cleveland Browns, as well as the Indianapolis Colts aiming to spark running back Jonathan Taylor against the Tennessee Titans. Analysts Seth Walder, Eric Moody, and Pamela Maldonado contributed game predictions, fantasy advice, and betting odds across the schedule.