Texans vs. Colts prediction, odds, picks: Misery continues for Daniel Jones

The Houston Texans face the Indianapolis Colts in an NFL matchup where both teams aim to avoid an 0-3 start. Houston enters the contest favored despite ruling out wide receiver Nico Collins due to a hamstring injury, which moved the betting spread from -2.5 to -1.5 points.

Indianapolis enters the game with several roster issues, as wide receiver Alec Pierce was placed on injured reserve. Through two games, the Colts' defense ranks last in the league in yards allowed per game and passing yards surrendered per contest.