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Juszczyk and Three More Ruled OUT vs. Seahawks in Week 5; Williams Questionable Ahead of #SFvsSEA

The San Francisco 49ers released their latest injury updates headed into their contest against the Seattle Seahawks.

By Brooke Evans · San Francisco 49ers

Published: Friday, 9 October 2026 at 10:07 PM

Key Things to Know

Kyle Juszczyk, Nick Bosa, James Thompson Jr., and Marques Sigle have been ruled out against Seattle.
Defensive lineman Mykel Williams and cornerback Upton Stout are listed as questionable for Week 5.
Williams returned to full practice participation Friday and is expected to be activated off the PUP list.

The Story in 60 Seconds

The San Francisco 49ers have ruled out fullback Kyle Juszczyk, defensive linemen Nick Bosa and James Thompson Jr., and safety Marques Sigle for Sunday's Week 5 matchup against the Seattle Seahawks. Head coach Kyle Shanahan confirmed the designations on Friday following the team's final practice of the week at Lumen Field.

Defensive lineman Mykel Williams and cornerback Upton Stout are listed as questionable ahead of the game. Williams logged a full practice on Friday after recovering from an ACL injury and is expected to be activated, while wide receiver Mike Evans cleared game designations despite battling a rib injury.

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Juszczyk and Three More Ruled OUT vs. Seahawks in Week 5; Williams Questionable Ahead of #SFvsSEA

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