NFL Week 6 best bets for Sunday’s games

ESPN analysts Ben Solak, Seth Walder, Matt Bowen, and fantasy analyst Mike Clay provide betting analysis and predictions for NFL Week 6. Bowen selects the Jacksonville Jaguars to cover a 2.5-point spread against the Houston Texans at Wembley Stadium in London, also backing the under on the total. Solak recommends betting overs on Texans quarterback C.J. Stroud and wide receiver Nico Collins against a vulnerable Jacksonville pass defense.

Additional player props and model-driven picks highlight key lineup developments across the league. Solak targets an under on Los Angeles Rams quarterback Matthew Stafford's passing yards and expects heavy underneath volume for Philadelphia Eagles backup quarterback Tanner McKee with Jalen Hurts sidelined by a blood clot. Walder relies on statistical projections for defensive props, while Clay offers implied-odds touchdown probabilities.