Super Bowl odds: 49ers remain favorites ahead of Bills, Chiefs after first loss

The San Francisco 49ers remain the favorites to win the Super Bowl at +575 odds on BetMGM, holding off the Buffalo Bills (+600) despite suffering their first defeat in Week 7 against Atlanta. Thirteen NFL teams currently have title odds shorter than +2200, representing the most concentrated field of contenders at this stage of the season in the last 15 years.

Key matchups in Week 8 could dramatically alter the championship picture. Buffalo faces the Baltimore Ravens, while the Kansas City Chiefs (+900) travel to play the Denver Broncos following a loss to the Seattle Seahawks. In the NFC, the undefeated Minnesota Vikings visit the Detroit Lions, and the Seahawks, who recently acquired guard Quenton Nelson, host the Chicago Bears.